超星 - test 5 - 查题吧

单选题

On 24 May 2019, Zolgensma (onasemnogene abeparvovec-xioi, AVXS-101) was approved by the FDA indicated for the treatment of pediatric patients less than ___ years of age with spinal muscular atrophy (SMA) with biallelic mutations in the survival motor neuron 1 (SMN1) gene.

A. 1
B. 2
C. 3
D. 5

单选题

_____________ is the first therapeutic treatment approved to treat the rare and fatal spinal muscular atrophy (SMA) disease. SMA is a severe neuromuscular disease that causes extreme muscle weakness and paralysis caused by a genetic defect in the SMN1 gene.

A. Luxturna
B. Kymriah
C. Zolgensma
D. Yescarta

单选题

Spinal muscular atrophy (SMA)is diagnosed in approximately one out of every _________ live births and is the leading genetic cause of infant mortality.

A. 8,000
B. 10,000
C. 12,000
D. 15,000

单选题

Zolgensma is supplied as a suspension for intravenous administration. It is for single-dose intravenous infusion only. The recommended dosage of Zolgensma is 1.1×_______ vector genomes (vg) per kg of body weight. Zolgensma is administered as an intravenous infusion over 60 minutes.

A. 10^10
B. 10^12
C. 10^14
D. 10^16

单选题

Zolgensma is provided in a kit containing 2 to 9 vials, as a combination of 2 vial fill volumes (either 5.5 ml or 8.3 ml). All vials have a nominal concentration of 2.0×_______ vector genomes (vg) per ml. Each vial contains an extractable volume of not less than either 5.5 ml or 8.3 ml.

A. 10^12
B. 10^13
C. 10^14
D. 10^16

单选题

Themostcommonadversereactions(incidence≥5%) of Zolgensma are elevatedaminotransferasesand___________.

A. nausea
B. vomiting
C. fever
D. headache

单选题

Thedoctorsshouldadministersystemic______________toallpatientsbeforeandafterZolgensmainfusionandcontinuetomonitorliverfunctionforatleast3monthsafterinfusion.

A. aspirin
B. vitaminC
C. corticosteroid
D. ibuprofen

单选题

When a cell or individual is treated using gene therapy and successful incorporation of engineered genes has occurred, the cell or individual is said to be ______________.

A. transparent
B. transgenic
C. transporting
D. transforming

单选题

In gene therapy, one approach to gene regulation is to attach other genes that detect certain biological activities and then react as a type of automatic off-and-on _________ that regulates the activity of other genes according to biological cues.

A. trigger
B. gate
C. switch
D. circuit

单选题

In _______, Nature published UK's first human germline editing study conducted by the developmental biologist Kathy Niakan at the Francis Crick Institute in London.

A. 2013
B. 2015
C. 2017
D. 2019

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