超星 - test 5 - 查题吧

判断题

The FDA required that clinicians who dispense tisagenlecleucel are specially certified on prescribing, dispensing, and administering this medication and on recognizing and managing CRS and the associated neurologic adverse reactions.

A. 对
B. 错

判断题

Since the CD199 antigen is also present on normal B-cells, and Kymriah will also destroy those normal B cells that produce antibodies, there may be an increased risk of infections for a prolonged period of time.

A. 对
B. 错

判断题

Gene therapy involves a whole lot of complicated sets of activities involving tissue targeting, cellular trafficking, delivery of genes to organs, safety of the vector, activity of therapeutic protein, etc.

A. 对
B. 错

判断题

Gene therapy seems elegantly complicated in its concept: supply the human body with a gene that can correct a biological malfunction that causes a disease. However, there are many obstacles and some distinct questions concerning the viability of gene therapy.

A. 对
B. 错

判断题

Some viral vectors, like the adenoviruses, often are recognized and destroyed by the immune system so their therapeutic effects are long-lived.

A. 对
B. 错

判断题

In gene therapy, maintaining gene expression so it performs its role properly after vector delivery is difficult. As a result, some therapies need to be repeated often to provide short-lasting benefits.

A. 对
B. 错

判断题

In gene therapy, vector–chromatin interaction and its consequences have become more unpredictable, but vector-induced leukemogenesis remains an predictable factor in gene therapy due to its multifactorial nature.

A. 对
B. 错

判断题

Indeed, the success and feasibility of gene therapy is undeniable considering that the majority of the more than 60 patients treated for ADA-SCID and SCID-X1 within the last two decades experienced a clear clinical benefit.

A. 对
B. 错

判断题

Despite the occurrence of leukemia in some of these patients the overall success rate of gene therapy outperforms the results obtained after allogeneic HSCT with HLA-mismatched donors.

A. 对
B. 错

判断题

Potential adverse effects of gene therapy have to be balanced against the clinical benefit expected for the individual patient, taking into consideration the clinical complications associated with alternative treatment options.

A. 对
B. 错

3