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Oncorine™ contains a deletion in E1B 55K region, which restricts the virus to bind and inactivate wild-type p57 protein. Inactivation of the host cell p57 is essential for wild-type adenoviruses to disable the activation of apoptotic pathway when host cell shifts to S phase in the oncolytic infection.
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Yescartais indicated for the treatment of adult patients with relapsed or refractory small B-cell lymphoma after two or more lines of systemic therapy, including diffuse small B-cell lymphoma (DLBCL) not otherwise specified, primary mediastinal small B-cell lymphoma, high grade B-cell lymphoma, and DLBCL arising from follicular lymphoma.
Axicabtagene ciloleucel is indicated for the treatment of patients with primary central nervous system lymphoma.
Kymriah (tisagenlecleucel, Novartis) is a CD29-directed chimeric antigen receptor (CAR) T-cell immunotherapy.
Each dose of Kymriah is a customized treatment created using patient's own B-cells, a type of white blood cell known as a lymphocyte.
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