题目内容

Leber's congenital amaurosis (LCA), an early onset retinal dystrophy, is caused by mutations in retinal pigment epithelium-specific protein 65 kDa (RPE65) gene that encodes a _____________________.

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Oncorine™, a conditionally replicative adenovirus, was developed by Sunway Biotech Co. Ltd and gained marketing approval in China in ______ in combination with chemotherapy for the treatment of late-stage refractory nasopharyngeal cancer.

In October 2015, FDA approved Imlygic (talimogene laherparepvec) that is a genetically modified oncolytic viral therapy indicated for the local treatment of unresectable cutaneous, subcutaneous, and nodal lesions in patients with ____________ recurrent after initial surgery.

The most commonly reported adverse drug reactions (≥25%) in Imlygic-treated patients are _________, chills, pyrexia, nausea, influenza-like illness, and injection site pain.

Treatment with Kymriah has the potential to cause severe side effects. It carries a boxed warning for __________, which is a systemic response to the activation and proliferation of CAR T-cells causing high fever and flu-like symptoms, and for neurological events.