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There are still multiple issues to be addressed in gene therapy before gene‐based products enter routine clinical application to provide safe and affordable __________________ for otherwise non-treatable overt and chronic diseases.
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Although gene therapy is a promising treatment option for a number of diseases (including inherited disorders, some types of cancer, & certain viral infections), the technique remains risky & is still under study to make sure that it will be safe & effective.
More than 5,400 clinical trials of gene therapy have completed. There are >1,000 clinical trials ongoing, about 70 in Phase III trials.
Oncorine™ contains a deletion in E1B 55K region, which restricts the virus to bind and inactivate wild-type p27 protein. Inactivation of the host cell p27 is essential for wild-type adenoviruses to disable the activation of apoptotic pathway when host cell shifts to S phase in the oncolytic infection.
US FDA defines gene therapy as products "that mediate their effects by transcription and/or translation of transferred genetic material and/or by integrating into the host genome and that are administered as nucleic acids, viruses, or genetically engineered microorganisms. The products may be used to modify cells in vivo or transferred to cells ex vivo prior to administration to the recipient."
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