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With long-term immunosuppression using more potent medications, _____________________ was noted to be a hazard of organ transplantation and immunosuppressive therapy. This association was first reported in 1968 by Starzl at the Swiss Society of Immunology and the American Surgical Association.

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By1971,neoplasmsofthelymphoreticularsystemweretheonlymalignanciesknowntobeassociatedwiththeuseofimmunosuppressivemedications.Thatyear,BrienWalderandcolleaguesfromNewSouthWales,Australia,reportedthat7(14%)of51renaltransplantrecipientshadatotalof20_________________________4to45monthsaftertransplantation.Allpatientshadbeentreatedwithprednisoneandazathioprine.

In 2018, the US has performed ________ transplants. Chinese people have donated 17,898 organs.

In WHO's Guiding Principles on Human Organ and Tissue Transplantation (2009), its Guiding Principle 2 declares that, "Physicians determining that a potential donor has died should not be directly involved in cell, tissue or organ removal from the donor or subsequent transplantation procedures; nor should they be responsible for the care of any ___________________ of such cells, tissues and organs."

Brain death is distinct from a _____________________, whether induced medically or caused by injury and/or illness, even if it is very deep, as long as some brain and bodily activity and function remains; and it is also not the same as the condition known as 'locked-in syndrome'.