Whichofthefollowingstatementsabouttheviralvectorsforgenetherapyiswrong?
Anumberofviruseshavebeenusedforhumangenetherapy,includingretroviruses,adenoviruses,herpessimplex,vaccinia, and adeno-associatedvirus.
B. Inordertoreplicate,virusesneverintroducetheirgeneticmaterialintothehostcell,trickingthehost'scellularmachineryintousingitasblueprintsforviralproteins.
C. Retrovirusesgoastagefurtherbyhavingtheirgeneticmaterialcopiedintothegenomeofthehostcell.
D. Likethegeneticmaterial(DNAorRNA)inviruses,therapeuticDNAcanbedesignedtosimplyserveasatemporaryblueprintthatisdegradednaturallyor(atleasttheoretically)toenterthehost'sgenome,becomingapermanentpartofthehost'sDNAininfectedcells.
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Whichofthefollowingstatementsaboutthenon-viralvectorsforgenetherapyiswrong?
A. Non-viralmethodspresentcertainadvantagesoverviralmethods,suchaslargescaleproduction&lesssafetyconcerns.
B. Methodsfornon-viralgenetherapyincludetheinjectionofnakedDNA,electroporation,thegenegun,sonoporation,magnetofection,theuseofoligonucleotides,lipoplexes,dendrimers,&inorganicnanoparticles.
C. Non-viralmethodsoftenproducehighlevelsoftransfectionandgeneexpression,&thusincreasetherapeuticefficacy.
D. Generallynon-viralmethodshavealowhostimmunogenicity.
Which of the following viruses is the most commonly used vector in gene therapy?
A. nakes plasmid
B. adenovirus
C. retrovirus
D. adeno-associated virus (AAV)
Which of the following virus is the most commonly used vector for gene therapy?
AAV
B. adenovirus
C. retrovirus
D. lentivirus
Totreatthepatientswithcysticfibrosis,doctorsneedtocorrectthedefective________gene.
ABCD1
B. ABCA4
CFTR
D. GAD
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