The mechanism of mucosal invasion by C. albicans is at least partially understood. Which one of the following modifications in the structure or function of this yeast would be most likely to affect its invasive ability?

A. Loss of ability to produce ethanol from glucose
B. Loss of ability to produce germ tubes or hyphae
C. Reduced ability to grow at 37°C
D. Loss of ability to produce a polysaccharide capsule
E. Replacement of mannans in the cell wall with glucan