In 1973 Herbert Wayne Boyer at UCSF (1936- ) and Stanley Norman Cohen at Stanford University (1935- ) created the first recombinant DNA organisms. Together they introduced an antibiotic resistance gene into _______.
A. elegans
B. yeast
C. coli
D. mice
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In 1983, a group of scientists from Baylor College of Medicine in Houston, Texas, proposed that gene therapy could one day be a viable approach for treating Lesch-Nyhan disease, a rare ___________________.
A. blood disorder
B. neurological disorder
C. bone disorder
D. joint disorder
In ______, Glybera (alipogene tiparvovec) became the first approved viral gene-therapy treatment for familial lipoprotein lipase deficiency (LPLD) in Europe.
A. 2006
B. 2010
C. 2012
D. 2015
The marketing authorization for Glybera clearly represents a milestone in the development of gene therapy as an accessible therapeutic option for familial lipoprotein lipase deficiency (LPLD) patients. Glybera is a recombinant __________ for direct intramuscular injection.
A. adenovirus
B. AAV
C. HPV
D. retrovirus
In March 2017, Yescarta (axicabtagene ciloleucel), a ________-directed genetically modified autologous T cell immunotherapy, was approved by FDA.
A. CD15
B. CD19
CD29
D. CD44