题目内容
Some vectors, like retroviruses, can enter cells functioning properly and interfere with the ____________________________, possibly leading to other diseases.
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There are still multiple issues to be addressed in gene therapy before gene‐based products enter routine clinical application to provide safe and affordable __________________ for otherwise non-treatable overt and chronic diseases.
Although gene therapy is a promising treatment option for a number of diseases (including inherited disorders, some types of cancer, & certain viral infections), the technique remains risky & is still under study to make sure that it will be safe & effective.
More than 5,400 clinical trials of gene therapy have completed. There are >1,000 clinical trials ongoing, about 70 in Phase III trials.
Oncorine™ contains a deletion in E1B 55K region, which restricts the virus to bind and inactivate wild-type p27 protein. Inactivation of the host cell p27 is essential for wild-type adenoviruses to disable the activation of apoptotic pathway when host cell shifts to S phase in the oncolytic infection.
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