一部反映19世纪末期中国某富商家族兴衰历史的电视剧正在热播，剧中有这样几组镜头，其中与史实不符的是（）
A. 镜头一：商人到日本人在苏州开设的工厂谈生意
B. 镜头二：商人的儿子在《申报》报社当记者
C. 镜头三：商人正在读《新青年》，了解新闻时事
D. 镜头四：商人家住北京东交民巷
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关于商务印书馆以下信息错误的是（ ）
A. 它创办于1987年
B. 在近代历史上它出版了很多课本和字典
C. 它创办于上海
D. 它是近代中国历史最长、规模最大的文化出版机构
Whichofthefollowingstatementsabouttheviralvectorsforgenetherapyiswrong?
Anumberofviruseshavebeenusedforhumangenetherapy,includingretroviruses,adenoviruses,herpessimplex,vaccinia, and adeno-associatedvirus.
B. Inordertoreplicate,virusesneverintroducetheirgeneticmaterialintothehostcell,trickingthehost'scellularmachineryintousingitasblueprintsforviralproteins.
C. Retrovirusesgoastagefurtherbyhavingtheirgeneticmaterialcopiedintothegenomeofthehostcell.
D. Likethegeneticmaterial(DNAorRNA)inviruses,therapeuticDNAcanbedesignedtosimplyserveasatemporaryblueprintthatisdegradednaturallyor(atleasttheoretically)toenterthehost'sgenome,becomingapermanentpartofthehost'sDNAininfectedcells.
Whichofthefollowingstatementsaboutthenon-viralvectorsforgenetherapyiswrong?
A. Non-viralmethodspresentcertainadvantagesoverviralmethods,suchaslargescaleproduction&lesssafetyconcerns.
B. Methodsfornon-viralgenetherapyincludetheinjectionofnakedDNA,electroporation,thegenegun,sonoporation,magnetofection,theuseofoligonucleotides,lipoplexes,dendrimers,&inorganicnanoparticles.
C. Non-viralmethodsoftenproducehighlevelsoftransfectionandgeneexpression,&thusincreasetherapeuticefficacy.
D. Generallynon-viralmethodshavealowhostimmunogenicity.
Which of the following viruses is the most commonly used vector in gene therapy?
A. nakes plasmid
B. adenovirus
C. retrovirus
D. adeno-associated virus (AAV)
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