题目内容

Which of the following statements about the doses ofImlygic are correct?

A. The total injection volume for each treatment by Imlygic visit should not exceed 4 ml for all injected lesions combined.It may not be possible to inject all lesions at each treatment visit or over the full course of treatment.
B. Previously injected and/or uninjected lesion(s) may be injected at subsequent treatment visits.
C. The initial recommended dose is up to 4 ml of Imlygic at a concentration of 10^6 (1 million) PFU per ml.
D. The recommended dose for subsequent administrations is up to 4 ml of Imlygic at a concentration of 10^8 (100 million) PFU per ml.

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Presently, gene therapies for the following diseases are being developed:

A. cystic fibrosis (using adenoviral vector)
B. HIV infection (cell-based)
C. malignant melanoma (cell-based)
Duchenne muscular dystrophy (cell-based)

Presently,genetherapiesforthefollowingdiseasesarebeingdeveloped:

A. hemophilia B (cell-based)
B. kidney cancer (cell-based)
C. Gaucher's Disease (retroviral vector)
D. breast cancer (retroviral vector)

Ethicalissuesongenetherapyinclude:

A. Howcan"good"and"bad"usesofgenetherapybedistinguished?
B. Whatactuallyhappenswhenthingsgowrong?
C. Whodecideswhichtraitsarenormalandwhichconstituteadisabilityordisorder(decidingproperindications)?
Dowehaveenoughknowledgetomaketherightdecisions?

Ethicalissuesongenetherapyinclude:

Areweabletocontrolgenetherapy?Aretheresituations,whengenetherapyisethicallymoreacceptable?
B. Whatarethecostsforthistypeoftherapyandwhoispayingforit?Willthehighcostsofgenetherapymakeitavailableonlytothewealthy?
Couldthewidespreaduseofgenetherapymakesocietylessacceptingofpeoplewhoaredifferent?
D. Whatisthepotentialimpactofgermlinegenetransferonfuturegenerations?

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