Which mechanism about how LPS induces fever is not right?
A. LPS stimulate monocytes in blood to release IL6,IL1 and TNFa;
B. IL6,IL1 and TNFa are called endougenous pyrogens to stimulate hypothalamus and induce fever ;
C. IL6,IL1 and TNFa are elevated and circulaedin blood to reach brain;
D. LPS enter blood to reach hypothalamus directly to induce fever.