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The sensation of pain cannot accurately be described as "located" at the point of an injury, or, for that matter, in any one place in the nerves or brain. Rather, pain signals—and pain relief—are delivered through a highly complex interacting circuitry. When a cell is injured, a rush of prostaglandin s sensitizes nerve endings at the injury. Prostaglandins are chemicals produced in and released from virtually all mammalian cells when they are injured: these are the only pain signals that do not originate in the nervous sys- tern. Aspirin and other similar drugs(such as indomethacin and ibuprofen)keep prostaglandins from being made by interfering with an enzyme known as prostaglandin synthetase, or cyclooxy- genase. The drugs effectiveness against pain is proportional to their success in blocking this enzyme at the site of injury. From nerve endings at the injury, pain signals move to nerves feeding into the spinal cord. The long, tubular membranes of nerve cells carry electrical impulses. When electrical impulses get to the spinal cord, a pain-signaling chemical known as substance P is released there. Substance P then excites nearby neurons to send impulses to the brain. Local anesthetics such as novo-caine and xylocaine work by blocking the electrical transmission along nerves in a particular area. They inhibit the flow of sodium ions through the membranes, making the nerves electrically quiescent; thus no pain signals are sent to the spinal cord or to the brain. Recent discoveries in the study of pain have involved the brain itself—the supervising organ that notices pain signals and that sends messages down to the spinal cord to regulate incoming pain traffic. Endorphins-—the brain s own morphine—are a class of small peptides that help to block pain signals within the brain itself. The presence of endor- phins may also help to explain differences in response to pain signals, since individuals seem to differ in their ability to produce endorphins. It now appears that a number of techniques for blocking chronic pain—such as acupuncture and electrical stimulation of the central brain stem—involve the release of endorphins in the brain and spinal cord.<br>The passage is primarily concerned with

A. analyzing ways that enzymes and other chemicals influence how the body feels pain.
B. describing the presence of endorphins in the brain and discussing ways the body blocks pain within the brain itself.
C. describing how pain signals are conveyed in the body and discussing ways in which the pain signals can be blocked.
D. demonstrating that pain can be influenced by acupuncture and electrical stimulation of the central brain stem.
E. differentiating the kinds of pain that occur at different points in the body" s nervous system.

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Until recently most astronomers believed that the space between the galaxies in our universe was a near perfect vacuum. This orthodox view of the universe is now being challenged by astronomers who believe that a heavy "rain" of gas is falling into many galaxies from the supposedly empty space around them. The gas apparently con- denses into a collection of small stars, each a little larger than the planet Jupiter. These stars vastly outnumber the other stars in a given galaxy. The amount of " intergalactic rainfall" into some of these galaxies has been enough to double their mass in the time since they formed. Scientists have begun to suspect that this intergalactic gas is probably a mixture of gases left over from the "big bang" when the galaxies were formed and gas was forced out of galaxies by supernova explosions. It is well known that when gas is cooled at a constant pressure its volume decreases. Thus, the physicist Fabian reasoned that as intergalactic gas cools, the cooler gas shrinks inward toward the center of the galaxy. Meanwhile its place is taken by hotter intergalactic gas from farther out on the edge of the galaxy, which cools as it is compressed and flows into the galaxy. The net result is a continuous flow of gas, starting as hot gases in inter galactic space and ending as a drizzle of cool gas called a "cooling flow," falling into the central galaxy. A fairly heretical idea in the 1970s, the cooling-flow theory gained sup- port when Fabian observed a cluster of galaxies in the constellation Perseus and found the central galaxy, NGC 1275, to be a strange-looking object with irregular, thin strands of gas radiating from it. According to previous speculation, these strands were gases that had been blown out by an explosion in the galaxy. Fabian, however, disagreed. Because the strands of gas radiating from NGC 1275 are visible in optical photographs, Fabian suggested that such strands consisted not of gas blown out of the galaxy but of cooling flows of gas streaming inward. He noted that the wavelengths of the radiation emitted by a gas would changes as the gas cooled, so that as the gas flowed into the galaxy and became cooler, it would emit not x-rays, but visible light, like that which was captured in the photographs. Fabians hypothesis was supported by Canizares determination in 1982 that most of the gas in the Perseus cluster was at a temperature of 80 mil lion degrees Kelvin, whereas the gas immediately surrounding NGC 1275(the subject of the photographs)was at one-tenth this temperature.<br>The primary purpose of the passage is to

A. illustrate a hypothesis about the origin of galaxies.
B. provide evidence to dispute an accepted theory about the evolution of galaxies.
C. summarize the state of and prospects for research in intergalactic astronomy.
D. report new data on the origins of intergalactic gas.
E. reconcile opposing views on the formation of intergalactic gas.

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