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Of the Gram-positive organisms, aerobic, endospore-forming bacteria of the genus bacillus, some coryneform bacteria (Corynebacter-ium and Brevibacterium) and the filamentous bacteria (actinomycetes) particularly of the genus Streptomyces are well represented.
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Gram-negative types include acetic acid bacteria and Xanthomonads(黄单胞杆菌).
The relevant characteristics of these microorganisms are that they should be non-pathogenic, easy to maintain and cheap to grow.
Escherichia coli, bacilus subtilis and Saccharomyces cerevisiae are being developed as hosts for genetically engineered genes and as such are potentially able to synthesize a range of products.
This simplicity has led to an obligate requirement for intracellular growth and a heavy dependence on host cell structural and metabolic components.
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