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Most of the ethical discussions related to genome editing center around human germline editing. This is because changes made in the germline would be passed down to future generations.
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Due to the possibility of off-target effects (edits in the wrong place) and mosaicism (when some cells carry the edit but others do not) of genome editing, safety is of primary concern.
Some researchers and bioethicists are concerned that any genome editing, even for therapeutic uses, will start us on a slippery slope to using it for non-therapeutic and enhancement purposes, which many view as controversial.
It is concerned that the use of genome editing for reproductive purposes will be regulated differently in different countries leading to international unfairness.
Some people worry that it is impossible to obtain informed consent for germline therapy because the patients affected by the edits are the embryo and future generations.
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