They have made great ____ to the relief funds.
A. contributions
B. help
C. aids
D. money
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He is a new comer, so he is nor so familiar ___ the work.
A. to
B. with
C. at
D. on
She tried to make herself understood ___ signs .
A. by means of
B. by any means
C. in means of
D. by no means
However I am busy, I always ____ calling my mother.
A. get around to
B. set to
C. pay attention to
D. do my best to
He was ____ responsible for the accident.
A. regardless of
B. in spite of
C. despite
D. to a certain degree