题目内容

There are two mechanisms for stem cells to maintain self-renewal ability: obligatory asymmetric replication and ____________________.

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_____________ stem cells can produce only one cell type, their own, but have the property of self-renewal, which distinguishes them from non-stem cells (e.g. progenitor cells, which cannot self-renew).

LIF and ________ are two polycomb family proteins.

Ahumanembryonicstemcell (ESC) is definedbytheexpressionofseveral__________________________andcellsurfaceproteins. Oct-4,Nanog,&Sox2formthecoreregulatorynetworkthatensuresthesuppressionofgenesthatleadtodifferentiationandthemaintenanceofpluripotency.

Duringembryonicdevelopmenttheinnercellmasscellscontinuouslydivideandbecomemore__________________.Withoutoptimalcultureconditionsorgeneticmanipulation,embryonicstemcellswillrapidlydifferentiate.