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In a 2013 review, Herman (Dow AgroSciences) and Price (FDA, retired) argued that transgenesis is less disruptive than traditional breeding techniques because the latter routinely involve more changes (mutations, deletions, insertions and rearrangements).
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The risk of horizontal gene transfer between GMO plants and animals is very low and in most cases is expected to be lower than background rates.
The General Accounting Office (in a review of FDA procedures requested by Congress) and a working group of the Food and Agricultural and World Health organizations both said that long-term human studies of the effect of GM food are not feasible.
American Association for the Advancement of Science (AAAS) claims that, "The World Health Organization, the American Medical Association, the U.S. National Academy of Sciences, the British Royal Society, and every other respected organization that has examined the evidence has come to the same conclusion: consuming foods containing ingredients derived from GM crops is no riskier than consuming the same foods containing ingredients from crop plants modified by conventional plant improvement techniques."
Potential environmental effects of GM crops include gene flow, pesticide resistance and greenhouse gas emissions.
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