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Tissue necrosis and abscess formation limit drug penetration and can impede antibiotic activity. ( )

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Allopurinol, an xanthine oxidase inhibitors, decreases the production of uric acid. ( )

Metformin is the first choice of drug for type 2 diabetes mellitus(T2DM), especially for obese patients with T2DM. ( )

Diagnostic criteria of diabetes: Fasting Plasma Glucose() ≥7.8mmol/L,or OGTT 2h≥10.1mmol/L. ( )

T4 replacement therapy is used in hyperthyroidism. ( )