题目内容

患者男性,70岁,因“腹胀、双下肢水肿2个月余”来诊。患者无明显诱因出现腹胀,双下肢肿,尿量减少,色黄,食欲缺乏,无呕血、黑粪,无恶心、呕吐。否认肝炎、结核病史。吸烟20余年,20支/日,已戒;饮酒史50年,每日饮酒150~200g。查体:体温37.2℃,脉搏101次/分,呼吸20次/分,血压123/76mmHg(1mmHg=0.133kPa)。慢性病容,皮肤巩膜中度黄染,颈部可见蜘蛛痣。心肺无异常。腹膨隆,腹软,全腹无压痛及反跳痛,腹部未触及包块,肝脾肋下未触及,移动性浊音阳性。双肾未触及。双下肢轻度水肿。实验室检查:乙型病毒性肝炎标志物均阴性,甲胎蛋白(AFP)正常。肝功能示总胆红素107.2μmol/L,直接胆红素39μmol/L,白蛋白28g/L,丙氨酸氨基转移酶62.9U/L,天门冬氨酸氨基转移酶216U/L,碱性磷酸酶228U/L,谷氨酰转肽酶1148U/L。肾功能示血尿素氮7.6mmol/L,肌酐74μmol/L。血电解质:血钾3.56mmol/L,血钠133.5mmol/L。凝血常规:凝血酶原时间16.0s,活化部分凝血活酶时间35.7s,纤维蛋白原1.09g/L。影像学检查:上腹部CT示腹腔积液、脂肪肝,胃底、脾门血管迂曲。诊断:酒精性肝硬化失代偿期。若利尿效果不明显,可适当增加螺内酯的剂量,每日最大剂量是()

A. 120mg
B. 160mg
C. 200mg
D. 300mg
E. 400mg
F. 500mg

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