题目内容

Which one of the following is not the physical and chemical factors affecting the design of oral sustained and controlled release preparations.

A. stability
B. Water solubility
C. Partition coefficient
D. half-life
E. PKa

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The half-life of the drug that is suitable for the preparation of sustained/controlled-release preparations is

A. <1 h
B. 2-8 h
C. 24-32 h
D. >48 h

The dosage of drug for a general preparation is 3 times a day, 100mg each time. Now you are plan to design a sustained-relese preparation, and take medicine once a day. What dosage should you choose?

A. 150mg
B. 200mg
C. 250mg
D. 300mg
E. 350mg

A drug is absorbed in stomach and small intestine, now we plan to deisgn a sustain-release preparation, how long is the proper interval to take medicine?

A. 6h
B. 12h
C. 18h
D. 24h
E. 36h

Compare with general preparations, thebioavailability for sustained/controlled should be in the range of

A. 80-100%
B. 100-120%
C. 80-125%
D. 90-110%

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