题目内容

Syntheticbiologyisapowerfultoolforthestudyofnewlydesignedandsynthesizedbiologicalsystemswithamazingnovelfunctions.Itspotentialapplicationsinclude:

A. agriculture
B. clinical diagnosis
C. military applications
D. food science & engineering

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The genes in JCV-syn3.0 can be classified into 4 major functional groups:

A. 1. genes responsible for the expression of genome information (195 genes)
B. 2. genes responsible for the preservation of genome information (34 genes)
C. 3. genes for maintaining cell membrane structure & function (84 genes)
D. 4. genes responsible for cytosolic metabolism (81 genes)

Whichofthefollowingstatementsabout "ThePrinciplesfortheOversightofSyntheticBiology" (2012)arecorrect?

A. OnMar13,2012,over100environmentalandcivilsocietygroups,includingFriendsoftheEarth,theInternationalCenterforTechnologyAssessmentandtheETCGroupissuedthemanifestoThePrinciplesfortheOversightofSyntheticBiology.
B. Thismanifestocallsforaworldwidemoratoriumonthereleaseandcommercialuseofsyntheticorganismsuntilmorerobustregulationsandrigorousbiosafetymeasuresareestablished.
C. Thegroupsspecificallycallforanoutrightbanontheuseofsyntheticbiologyonthehumangenomeorhumanmicrobiome.
D. RichardLewontinwrotethatsomeofthesafetytenetsforoversightdiscussedinThePrinciplesfortheOversightofSyntheticBiologyarereasonable,butthatthemainproblemwiththerecommendationsinthemanifestoisthat"thepublicatlargelackstheabilitytoenforceanymeaningfulrealizationofthoserecommendations".

Which of the following statements about "IASB: Technical Solutions for Biosecurity in Synthetic Biology (2008)" are correct?

A. TheassemblyofartificialDNAintofunctionalgenesandtheproductionofproteinsfromsuchgenesisavailableasahighlystandardizedcommercialservice.Thisinternationalindustrycurrentlyfillsthousandsofordersforwholegenesandmillionsofordersforshortoligonucleotideseachday.
B. Insomeinstances,theseorderscompriseDNAsequencesderivedfrompathogenicorganisms,andinrarecasesfrompathogenswithanextremelyhighmortalityrate,suchastheEbolavirus.
C. ThemostfrequentlycitedlistsofbiologicalagentswithpotentialtoposeaseverethreattopublichealthandsafetyarepublishedbytheUSFederalRegister,FDA,NIAID,CDC,bytheAmericanandEuropeanSocietiesforMicrobiologyandbytheWHO.
D. Thereexistofcourseanumberofnationalregulationsthatdealwithbiosecurity.Mostcountries,includingtheUSAandEUmembers,havelegislationinplaceforthelimitationoftheexportofdualusegoods.ThisincludessyntheticDNA.

ThemajorsafetyconcernswithALife&syntheticbiologyare:

A. biosafety&biorisk:horizontalgenetransfer,theformationofantibiotic-resistantsuperbugs,etc.
B. bioterrorism(e.g.design&useofnewbiologicalweapons)
C. biosecurity:synthesisofdangerousbacteriaorviruses,e.g.poliovirusgenomesynthesizedin2002,theSpanishinfluenzavirusgenomesynthesizedin2005,theSARSvirusgenomesynthesizedin2008,theEbolavirusgenomesynthesizedin2016,&thehorsepoxvirusgenomesynthesizedin2017
D. environmentalrisk&impact:intentionalorunintentionalreleaseofsyntheticorganismsintotheenvironment

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