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During 2000-2003, several pathogen genomes were synthesized from scratch in the lab. This indicated the feasibility of _____________________________ of genomes from existing genomic sequences without reliance on natural templates.

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A circuit that showed robust, persistent oscillatory behaviour was developed by Hasty and colleagues in 2008, and was an impressive update to a series of experimental and theoretical studies on the design of ____________________.

In 2009, the European Molecular Biology Organization released the report "Making the Most of Synthetic Biology Strategies for Synthetic Biology Development in Europe" to introduce a ____________________ for European synthetic biology research.

To enable efficient genomic manipulation, Church and colleagues at Harvard Medical School developed a platform called multiplex automated genome engineering (MAGE) in 2011, which has been used to rapidly alter multiple loci in the E. coli genome, including the _____________________________ of all TAG stop codons with the synonymous TAA codon.

RNA-based circuit engineering also underwent an expansion during 2008-2013, as biosensing functions gave way to RNA-based computation. RNA devices were built to control the regulatory logic of gene expression, and RNA design tools were developed to enable the precise, predictable control of heterologous and ____________________________.