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In ______, azathioprine (the imidazole derivative of 6-mercaptopurine) was used with prednisone for immunosuppression. A combination of immunosuppressants, including prednisone, appeared to be more successful than the use of one drug alone.
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In _____, the first international exchange organization, Eurotransplant, was founded in Western Europe. This exchange program involved West Germany, Luxembourg, Belgium, and the Netherlands. There was no governmental involvement. The basis of the collaboration was the finding with HLA-typing that a good match gave a better result.
In ______, the first clinical successes with marrow transplants were reported in patients with rare congenital immunological deficits. But treating common blood malignancies was the real goal of marrow transplantation.
In 1969, Israel Penn and other colleagues of Starzl at the University of Colorado published the first paper on the development of malignancy (lymphomas) in ___ recipients of renal transplants. The malignancies were thought to be an indirect complication of organ transplantation and the measures taken to prevent rejection.
In Nov ______, Garcia-Rinaldi et al. published the design of a catheter for in situ preservation of cadaver kidneys for transplantation. This catheter was designed to be introduced through the femoral artery into the aorta and by inflating two balloons the segment of the aorta, where the renal arteries have their origin, is isolated. Through a third lumen the kidneys can be perfused with a cold solution and so the kidneys are preserved 'in situ' inside the body.
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