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Incomplete reprogramming is particularly challenging during iPSC generation because the genome-wide epigenetic code must be reformatted to that of the target cell type in order to fully reprogram a cell.
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Fanconianemiaisacommongeneticdisease.Amongthoseaffectedthemajoritydevelopcancer,mostoftenacutemyelogenousleukemia,and90%developbonemarrowfailure(theinabilitytoproducebloodcells)byage40.
Three separate groups were able to find mouse embryonic fibroblast (MEF)-derived iPSCs that could be injected into tetraploid blastocysts & resulted in the live birth of mice derived entirely from iPSCs, thus enhancing the debate over the equivalence of ESCs & iPSCs with regard to pluripotency.
Jessica Wing, a healthy, fit young woman, underwent three egg retrieval cycles in her early-mid twenties. At the age of 29, she developed metastatic colon cancer. She died two years later. DNA testing of her tissue revealed no genetic predisposition to colon cancer.
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