When the protocol of an animal study is reviewed by IACUC, the following items must be noted:
A. Rationale and purpose of the proposed use of animals
B. A clear and concise sequential description of the procedures involving the use of animals that is easily understood by all members of the committee
C. Availability or appropriateness of the use of less invasive procedures, other species, isolated organ preparation, cell or tissue culture, or computer simulation
D. Justification of the species and number of animals proposed; whenever possible, the number of animals and experimental group sizes should be statistically justified (e.g., provision of a power analysis)
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WhentheprotocolofananimalstudyisreviewedbyIACUC,thefollowingitemsmustbe carefully checked:
A. Unnecessary duplication of experiments
B. Nonstandard housing and husbandry requirements
C. Impact of the proposed procedures on the animals' well-being
D. Appropriate sedation, analgesia, and anesthesia (indices of pain or invasiveness might aid in the preparation and review of protocols)
WhentheprotocolofananimalstudyisreviewedbyIACUC,thefollowingitemsmustbecarefullychecked:
A. Conduct of surgical procedures, including multiple operative procedures
B. Postprocedural care and observation (e.g., Inclusion of post-treatment or postsurgical animal assessment forms)
C. Description and rationale for anticipated or selected endpoints
D. Criteria and process for timely intervention, removal of animals from a study, or euthanasia if painful or stressful outcomes are anticipated
WhentheprotocolofananimalstudyisreviewedbyIACUC,thefollowingitemsmustbecarefullychecked:
A. Method of euthanasia or disposition of animals, including planning for care of long-lived species after study completion
B. Adequacy of training and experience of personnel in the procedures used, and roles and responsibilities of the personnel involved
C. Use of hazardous materials and provision of a safe working environment
D. The costs of purchasing the animals
Main responsibilities of the personal license holder of animal use are:
A. Checking the welfare of experimental animals daily
B. Notifying the project license holder of breaches of the severity limit
C. Taking precautions as required to control severity
D. Seeking veterinary advice as required
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