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Synthetic biology is a field in constant and rapid development, so discussions on biosafety and biosecurity should evolve as old data are obtained and potential risks are identified.
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Bioterrorists could re-create known pathogenic viruses, make existing bacteria more dangerous, or make harmful biochemicals via in situ synthesis, among other possibilities.
New technologies, such as CRISPR–Cas-mediated genome editing, will enable synthetic biologists to take a less holistic engineering approach, modifying synthetic circuits and the host genome with relative ease.
Despite the proliferation of circuit design and construction methods, there is still very little sharing of circuit constructs between groups, as few synthetic networks are developed and then never used outside the home laboratory.
With respect to protocells, current fears are based on several unknowns: consequences of an eventual interaction between these systems and natural organisms, allergenicity, pathogenicity, etc., or the possibility of protocells interfering with natural vesicles produced by bacteria.
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