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Whenever pathogens infect laboratory animals, the immune system is activated regardless of the level of pathogenicity, and many agents also have the potential to induce _____________ of the immune system.

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Housing of animals is best conducted behind __________ barriers. The term "barrier" rather describes a program aiming at the prevention of pathogen introduction than just a certain design of a facility.

A greater risk arises from animals which have been bred or housed in experimental units where less attention may be paid to ____________ hygienic measures compared with breeding units.

On Aug 24 1966, the Laboratory Animal Welfare Act (P.L. 89-544) was signed into law. The Act sets minimum standards of care and housing for dogs, cats, primates, rabbits, hamsters and _________________ in the premises of animal dealers and laboratories, and it requires identification of dogs and cats to prevent theft.

The 3R principles in animal research refer to ______________, ______________, and _______________.

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