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The low induction efficiency may reflect the need for precise timing, balance, & absolute levels of expression of the reprogramming genes. It may also suggest a need for rare genetic and/or epigenetic changes in the original somatic cell population or in the prolonged culture. Depletion of Mbd3 improves reprogramming efficiency.
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Reprogramming of adult cells to obtain iPSCs never increase the risk of tumorigenecity.
Incomplete reprogramming is particularly challenging during iPSC generation because the genome-wide epigenetic code must be reformatted to that of the target cell type in order to fully reprogram a cell.
Fanconianemiaisacommongeneticdisease.Amongthoseaffectedthemajoritydevelopcancer,mostoftenacutemyelogenousleukemia,and90%developbonemarrowfailure(theinabilitytoproducebloodcells)byage40.
Three separate groups were able to find mouse embryonic fibroblast (MEF)-derived iPSCs that could be injected into tetraploid blastocysts & resulted in the live birth of mice derived entirely from iPSCs, thus enhancing the debate over the equivalence of ESCs & iPSCs with regard to pluripotency.
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