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Embryonic stem cells (ESCs) are _______________ and can give rise during development to all derivatives of the three primary germ layers: ectoderm, endoderm, & mesoderm. In other words, they can develop into each of the more than 200 cell types of the adult body.

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____________familyproteinsaidinstemcellself-renewalbysupressingtheexpressionofgenesassociatedwithdifferentiation.

There are two mechanisms for stem cells to maintain self-renewal ability: obligatory asymmetric replication and ____________________.

_____________ stem cells can produce only one cell type, their own, but have the property of self-renewal, which distinguishes them from non-stem cells (e.g. progenitor cells, which cannot self-renew).

LIF and ________ are two polycomb family proteins.