The latest and most effective therapy for AIDS patients includes azidothymidine (AZT), dideoxyinosine (DDI), and saquinavir or similar agents. Use of these three drugs would inhibit which of the following viral processes?
A. RNase, DNase
B. gp120 formation
C. p24 antibody expression
D. Reverse transcriptase andprotease
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An HIV-positive patient prior to being treated with AZT, DDI, and saquinavir has a CD4 lymphocyte count and an HIV RNA viral load test done. Results are as follows:CD4: 50 CD4 lymphocytes per microliterHIV RNA: 750,000 copies per ml Which of the following statements best describes the above patient?
A. This patient is no longer in danger of opportunistic infection
B. The 5-year prognosis is excellent
C. The patient's HIV screening test is most likely negative
D. The viral load of 750,000 copies per ml suggests that the patient will respond to triple therapy
This HIV-positive patient with a viral load of 750,000 copies of HIV RNA/ml and a total CD4 count of 50 is at an increased risk for a number of infectious diseases. For which of the following diseases is the patient at no more added risk than an immunocompetent host?
A. Pneumocystic carinii pneumonia
B. Mycobacterial disease
C. Kaposi's sarcoma
D. Pneumococcal pneumonia
HIV-1 is classified as a member of the Lentivirus genus in the Retroviridae family. Lentiviruses
A. Contain a DNA genome
B. Cause tumors in mice
C. Infect cells of the immune system
D. Have related sequences endogenous in normal cells
E. Cause rapidly progressive neurologic diseas
Each of the following statements concerning HIV is correct except
A. Screening tests for antibodies and nucleic acid are useful to prevent transmission of HIV through transfused blood
B. The opportunistic infections seen in AIDS are primarily the result of a loss of cell-mediated immunity
C. Zidovudine (azidothymidine) inhibits the RNA-dependent DNA polymerase
D. The presence of circulating antibodies that neutralize HIV is evidence that an individual is protected against HIV-induced disease
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