The most common congenital infection is caused by
A. Varicella-zoster virus
B. Herpes simplex virus type 2
C. Human herpesvirus 8(Kaposi sarcoma herpesvirus)
D. Cytomegalovirus
E. Parvovirus
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Which one of the following is the best explanation for the selective action of acyclovir (acycloguanosine) in herpes simplex virus-infected cells ?
Acyclovir binds specifically to viral receptors only on the surface of the HSV-infected cell
B. Acyclovir is phosphorylated by a virus-encoded phosphokinase only within HSV-infected cells
C. Acyclovir selectively inhibits the RNA polymerase in theHSV virion
D. Acyclovir specifically blocks the matrix protein of HSV, thereby preventing release of progeny HSV
The serum of a newborn infant reveals a 1:32 CMV titer. The child is clinically asymptomatic. Which of the following courses of action would be advisable?
A. Repeat the CMV titer immediately
B. Wait 6 months and obtain another titer on the baby
C. Obtain a CMV titer from all siblings
D. Obtain an anti-CMV IgM titer from the mother
E. Obtain an anti-CMV IgM titer from the baby
Adults who have had varicella as children occasionally suffer a recurrent form of the disease, shingles. The agent causing these diseases is member of which of the following viral families?
A. Herpesvirus
B. Poxvirus
C. Reoviruse
D. Paramyxovirus
An immunocompromised person with history of seizures had an MRI that revealed a temporal lobe lesion. Brain biopsy results showed multinucleated giant cells with intranuclear inclusions. The most probable cause of the lesion is
A. Hepatitis C virus
B. Herpes simplex virus
C. Listeria monocytogenes
D. Coxsackievirus
E. Parvovirus
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