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Infected animals may show altered behaviour, suppressed body weight, or reduced life expectancy which may, for example, influence the tumor rate in a population.
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Animals from commercial breeders are usually monitored carefully, and insufficient information on their health status is in most cases available.
Despite thorough testing and appropriate management practices, the introduction of agents into a facility or parts of it can always be avoided. It is therefore important that animals in breeding units as well as in experimental units are regularly monitored to confirm their status.
Gnotobiotic animals play a minor role and are at present often used for animal experiments.
By the laws, each institution in the US must have an Institutional Animal Care and Use Committee (IACUC) to oversee and evaluate the institution's animal program to assure compliance with all the regulations.
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