题目内容
25% of mice transplanted with c-myc-induced iPSCs developed lethal teratomas. N-myc & L-myc have been identified to induce instead of c-myc with similar efficiency.
查看答案
搜索结果不匹配？点我反馈
更多问题
The low induction efficiency may reflect the need for precise timing, balance, & absolute levels of expression of the reprogramming genes. It may also suggest a need for rare genetic and/or epigenetic changes in the original somatic cell population or in the prolonged culture. Depletion of Mbd3 improves reprogramming efficiency.
Reprogramming of adult cells to obtain iPSCs never increase the risk of tumorigenecity.
Incomplete reprogramming is particularly challenging during iPSC generation because the genome-wide epigenetic code must be reformatted to that of the target cell type in order to fully reprogram a cell.
Fanconianemiaisacommongeneticdisease.Amongthoseaffectedthemajoritydevelopcancer,mostoftenacutemyelogenousleukemia,and90%developbonemarrowfailure(theinabilitytoproducebloodcells)byage40.
微信支付 
支付宝支付