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Case reports and case series studies describe the experience of a single patient or a group of patients with a similar diagnosis.
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Case reports can be used to test the presence of a statistical association.
Randomized clinical trials are deemed to be the gold standard in clinical research.
The most appropriate research strategy and the design of the study depend on two key factors: research question and available resources which include time, budget, equipment, and staff.
Efficacy (explanatory) trials test the efficacy of a treatment (or an intervention) among highly selected participants and under controlled conditions.
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