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There is no doubt that research complications due to overt infectious disease are insignificant and that animals with clinical signs of disease should not be used for scientific experiments.
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All infections, apparent or inapparent, are likely to increase biological variability and hence result in a decrease in animal use.
Infected animals may show altered behaviour, suppressed body weight, or reduced life expectancy which may, for example, influence the tumor rate in a population.
Animals from commercial breeders are usually monitored carefully, and insufficient information on their health status is in most cases available.
Despite thorough testing and appropriate management practices, the introduction of agents into a facility or parts of it can always be avoided. It is therefore important that animals in breeding units as well as in experimental units are regularly monitored to confirm their status.
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