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Neural stem cells in the brain give rise to its three major cell types: nerve cells (neurons) & two categories of non-neuronal cells —astrocytes & oligodendrocytes.
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Typically, there is a very small number of pluripotent adult stem cells in each tissue &, once removed from the body, their capacity to divide is limited, making generation of large quantities of stem cells difficult.
Epithelial stem cells in the lining of the digestive tract occur in deep crypts & give rise to several cell types: absorptive cells, goblet cells, Paneth cells, & enteroendocrine cells.
Muse cells (multi-lineage differentiating stress enduring cells) are a recently discovered pluripotent stem cell type found in multiple adult tissues, including adipose, dermal fibroblasts, & bone marrow. While rare, muse cells are identifiable by their expression of SSEA-3 & general mesenchymal stem cell markers such as CD105.
Use of stem cells from amniotic fluid can overcome the ethical objections to using human embryos as a source of cells.
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