超星 - test 5 - 查题吧

判断题

Alipogene tiparvovec or Glybera, e.g., at a cost of $1.6 million per patient, was reported in 2016 to be the world's most expensive drug.

A. 对
B. 错

判断题

Today, we know that the "transforming principle" Griffith observed was the DNA of the III-S strain bacteria. While DNA had been known to biologists since 1969, most assumed at the time that proteins carried the information for inheritance.

A. 对
B. 错

判断题

Joshua Lederberg (1925-2008), a pioneer in bacterial genetics and plasmid biology, and a visionary in gene therapy shared the 1968 Noble prize with George Beadle (1903-1989) and Edward L. Tatum (1909-1975). Lederberg won ½ of the prize for his discoveries concerning genetic recombination and the organization of the genetic material of bacteria. Both Beadle & Tatum won 1/4/ of the prize each for their discovery that genes act by regulating definite chemical events.

A. 对
B. 错

判断题

The 1970s and 1980s set the basis of molecular genetics and gene transfer in bacteria, then into animal and human cells, combined with selection systems for cultured cells and recombinant DNA technology.

A. 对
B. 错

判断题

Paul Berg (1926- )awarded the 1990 Nobel Prize in Chemistry "for his fundamental studies of the biochemistry of nucleic acids, with particular regard to recombinant-DNA".

A. 对
B. 错

判断题

Genetech, the first biotechnology company, was founded by Herb Wayne Boyer and venture capitalist Robert A. Swanson in 1979. Boyer served as vice president of Genentech from 1976 through his retirement in 1991.

A. 对
B. 错

判断题

In July 1990, Dr. Martin J. Cline at UCLA headed another highly controversial human trial designed to treat β-thalassemia without institutional approval. The experiment involved the removal of bone marrow cells from two patients in Jerusalem and Naples, and their subsequent transformation in vitro with plasmids carrying the β-globin gene and the herpes simplex virus thymidine kinase (HSV-tk) gene expected to provide a selective proliferative advantage to marrow cells once these were transplanted back into the patients.

A. 对
B. 错

判断题

OneoftheearliestgenetherapytrialswasconductedbyGrossmanetal.,in1992totreatapatientwithfamilialhypercholesterolemiabygeneticmodification in vivoofculturedhepatocytes.

A. 对
B. 错

判断题

According to the Journal of Gene Medicine (2012), during the 1990s, for 69% of human patients, the main target disease by gene therapy was cancer. But only 10% of protocols reached phase III.

A. 对
B. 错

判断题

The rather discouraging decade of the 1990s finished badly in September 1999 with the widely publicized death of Jesse Gelsinger, an 18-year-old man undergoing gene therapy for the kidney genetic disease ornithine transcarboxylase deficiency (OTCD) — a shadow over the whole field of gene-based therapies.

A. 对
B. 错

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