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Multipotent stem cells are found in amniotic fluid. These stem cells are very active, expand extensively without feeders and are not tumorigenic.
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25% of mice transplanted with c-myc-induced iPSCs developed lethal teratomas. N-myc & L-myc have been identified to induce instead of c-myc with similar efficiency.
The low induction efficiency may reflect the need for precise timing, balance, & absolute levels of expression of the reprogramming genes. It may also suggest a need for rare genetic and/or epigenetic changes in the original somatic cell population or in the prolonged culture. Depletion of Mbd3 improves reprogramming efficiency.
Reprogramming of adult cells to obtain iPSCs never increase the risk of tumorigenecity.
Incomplete reprogramming is particularly challenging during iPSC generation because the genome-wide epigenetic code must be reformatted to that of the target cell type in order to fully reprogram a cell.
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