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Induced pluripotent stem cells (iPSCs) are useful tools for drug development & modeling of diseases, & scientists hope to use them in transplantation & regenerative medicine. They represent a single source of cells that could be used to replace those lost to damage or disease.
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Induced pluripotent stem cells (iPSCs) differ from ESCs. They share many similar properties, such as pluripotency & differentiation potential, the expression of pluripotency genes, epigenetic patterns, embryoid body, & teratoma formation, & viable chimera formation, but there are many differences within these properties.
The chromatin of Induced pluripotent stem cells (iPSCs) appears to be more "closed" or methylated than that of embryonic stem cells (ESCs).
Multipotent stem cells are found in amniotic fluid. These stem cells are very active, expand extensively without feeders and are not tumorigenic.
25% of mice transplanted with c-myc-induced iPSCs developed lethal teratomas. N-myc & L-myc have been identified to induce instead of c-myc with similar efficiency.
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